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Topical negative pressure, also called vacuum-assisted closure, has been shown to help reduce wound depth and volume compared with a hydrocolloid gel and gauze regimen for wounds of any etiology. 30 However, clinically meaningful outcomes, such as healing time, have not yet been adequately studied. There is currently insufficient high-quality data to support the use of topical negative pressure for venous ulcers. 30 In addition, the therapy generally has not been used in clinical practice because of the challenge in administering both topical negative pressure and a compression dressing on the affected leg.