This obsession has become so common that Dr. Pope has come up with a term for it: Adonis Complex. What fuels it, he says, are the ridiculously outsized bodies purveyed by Hollywood, magazine covers, and even action-toy manufacturers (just check out the size of . Joe these days). "One of the biggest lies being handed to American men today is that you can somehow attain by natural means the huge shoulders and pectorals of the biggest men in the magazines," says Dr. Pope. "Generations of young men are working hard in the gym and wondering what on earth they're doing wrong. They don't realize that the 'hypermale' look that's so prevalent these days is essentially unattainable without steroids."
When tested in vitro , 7-keto appears to activate the beta subset of the estrogen receptor (ERβ) with an EC 50 around 500μM which is partially blocked by exemestane (aromatase inhibitor or AI); there was no apparent activity on the classical subset (ERα) and parent DHEA and DHEAS were eqipotent.  As activity was hindered with an AI and there was efficacy in HepG2 cells but not Hep293 (expressing  and not expressing  aromatase, respectively) it is though that 7-oxo can be metabolized into an estrogen. 
Overall, the overwhelming data and information shows that a good natural test booster will provide incredibly positive and wonderful benefits without any negative side effects . If you look hard enough, you may find a corner case here or there of something minor or annoying, but we haven’t seen them on any consistent type basis and definitely nothing like some of things you may be hearing with testosterone replacement therapies like AndroGel (which is NOT a Test booster….but rather a outside injection of testosterone).That’s because with natural Test boosters, you’re not injecting your body with outside ’re taking natural supplements that trigger and cause your own body to produce more of it’s own testosterone – naturally!