Propionate krebs cycle

In 1904, the German chemist Franz Knoop elucidated the steps in beta-oxidation by feeding dogs odd- and even-chain ω-phenyl fatty acids, such as ω-phenylvaleric acid and ω-phenylbutyric acid, respectively. The mechanism of beta-oxidation, . successive removal of two carbons, was realized when it was discovered that the odd-chain ω-phenylvaleric acid was metabolized to hippuric acid , and that the even-chain ω-phenylbutyric acid was metabolized to phenaceturic acid . At this time, any reaction mechanism involving oxidation at the beta carbon was as yet unknown in organic chemistry . [10] [11]

Propionate krebs cycle

propionate krebs cycle

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