Note. Methandienone oral, like any other oral steroid drug, with prolonged reception can provoke thickening of the membranes of the liver cells, as well as worsening of the conductivity of the bile ducts, which can lead to stagnation of bile and pain in the right side. Traditionally, it is advised to drink concomitant drugs such as karsila, essenciale, liv-52, allochol or oozool in order to avoid stagnation of bile and “clean” the liver. These drugs in fact not only do not help the liver during the course, but also harm it. Cholagogue preparations are divided into 2 groups: one strengthens the production of bile – choleretics (allochol, cholenzyme), others – cholekinetics, contribute to its outflow from the gall bladder into the intestine (holosas). Therefore, if you take drugs that promote the formation of bile, you will only aggravate the situation. Therefore, only Holosas can be used on the course of cholagogue! And hepatoprotectors (karsil, essenciale, etc.) have a membrane-stimulating effect on liver cells, which in turn leads to thickening of the hepatic wall and stagnation of bile, which is difficult to diffuse through a thick membrane. So hepatoprotectors are more reasonable to take after the course and in this case it’s better to stop your choice on Heptral and Hepa-merz (ademetionine).
There are also non-traditional ways of Methane administration: intermittent method, interval method, etc. Each of them has its own tasks. For example, intermittent method is supposed to work in the way that the drug has no negative impact on the endogenous testosterone production, but in fact it has, so the testosterone level is reduced anyway. The idea of the interval method is that it allegedly doesn’t build up a tolerance to the active ingredient and reduces the “pressure” on the liver. In practice, most often these methods are ineffective due to a number of reasons, so these methods are not recommended. Methane is not an appropriate drug to take between courses.
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