Fluticasone propionate japan

Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen , estrogen , or mineralocorticoid receptors , thereby producing anti-inflammatory and vasoconstriction effects. It has been shown to have a wide range of inhibitory effects on multiple cell types (. mast cell , eosinophil , neutrophil , macrophages , and lymphocytes ) and mediators (. histamine , eicosanoids , leukotrienes , and cytokines ) involved in inflammation . Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, due to its low systemic bioavailability .

Die häufigsten unerwünschten Wirkungen sind Candida-albicans -Infektionen der Mund- und Rachenschleimhaut ( Mundsoor ). Häufig werden auch Infekte der oberen Luftwege, Heiserkeit, Lungenentzündung bei COPD -Patienten, Kopfschmerzen , Müdigkeit, Verletzlichkeit der Haut und Blutergüsse beobachtet. Um eine unerwünschte Wirkung auf die Mund- und Rachenschleimhaut zu vermeiden, sollte nach der Inhalation der Mund mit Wasser gespült oder etwas gegessen werden. Zu den sehr seltenen unerwünschte Wirkungen gehören Quincke-Ödeme , Allergien , Cushing-Syndrom , Hemmung der Nebennierenrinden-Funktion , Wachstumsverzögerung bei Kindern und Jugendlichen, verminderte Knochendichte , Glaukom , Hyperglykämie, Angstgefühl, Schlafstörungen, Verhaltensveränderungen und paradoxer Bronchospasmus .

A twelve month study (Gaining Optimal Asthma ControL, GOAL), in 3416 adult and adolescent patients with persistent asthma, compared the safety and efficacy of Seretide versus inhaled corticosteroid (Fluticasone Propionate) alone to determine whether the goals of asthma management were achievable. Treatment was stepped up every 12 weeks until ** total control was achieved or the highest dose of study drug was reached. GOAL showed more patients treated with Seretide achieved asthma control than patients treated with ICS alone and this control was attained at a lower corticosteroid dose.

Eligible patients with a valid prescription for ADVAIR DISKUS (fluticasone propionate and salmeterol inhalation powder) or ADVAIR HFA (fluticasone propionate and salmeterol) Inhalation Aerosol who present this savings card at participating pharmacies will pay the first $10, and receive up to $50 off each 30-day prescription or refill of ADVAIR DISKUS or ADVAIR HFA applied to your out-of-pocket cost. This offer is good for up to 12 uses, and each 30-day supply counts as 1 use. Patient is responsible for applicable taxes, and remaining out of pocket cost, if any. This offer is limited to one per person and is nontransferable and cannot be combined with any other coupon, free trial or similar offer. No substitutions are permitted. Patients, pharmacists, and prescribers cannot seek reimbursement from health insurance or any third party for any part of the amount received by the patient through this offer. Offer must be presented along with a valid prescription for ADVAIR DISKUS or ADVAIR HFA at the time of purchase. Your acceptance of this offer must be consistent with the terms of any drug benefit plan provided to you by your health insurer. You agree to report your use of this coupon to your health insurer if required.

Fluticasone propionate japan

fluticasone propionate japan

Eligible patients with a valid prescription for ADVAIR DISKUS (fluticasone propionate and salmeterol inhalation powder) or ADVAIR HFA (fluticasone propionate and salmeterol) Inhalation Aerosol who present this savings card at participating pharmacies will pay the first $10, and receive up to $50 off each 30-day prescription or refill of ADVAIR DISKUS or ADVAIR HFA applied to your out-of-pocket cost. This offer is good for up to 12 uses, and each 30-day supply counts as 1 use. Patient is responsible for applicable taxes, and remaining out of pocket cost, if any. This offer is limited to one per person and is nontransferable and cannot be combined with any other coupon, free trial or similar offer. No substitutions are permitted. Patients, pharmacists, and prescribers cannot seek reimbursement from health insurance or any third party for any part of the amount received by the patient through this offer. Offer must be presented along with a valid prescription for ADVAIR DISKUS or ADVAIR HFA at the time of purchase. Your acceptance of this offer must be consistent with the terms of any drug benefit plan provided to you by your health insurer. You agree to report your use of this coupon to your health insurer if required.

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